Postdoctoral Researcher in molecular neuroanatomy

Lund University was founded in 1666 and is repeatedly ranked among the world’s top universities. The University has around 46 000 students and 8 500 staff based in Lund, Helsingborg and Malmö. We are united in our efforts to understand, explain and improve our world and the human condition.

Lund University welcomes applicants with diverse backgrounds and experiences. We regard equality, equal opportunities and diversity as a strength and an asset.

Description of workplace

The Molecular Neuroanatomy research group, led by Åsa Mackenzie, investigates the brain regions and neural circuits involved in the motor and non-motor symptoms of Parkinson’s disease. The group combines anatomical, molecular and functional approaches, with a particular focus on the subthalamic nucleus (STN), an important target for deep brain stimulation (DBS) in Parkinson’s disease.

We are now seeking a Postdoctoral Researcher to join an experimental research project investigating the organisation and function of brain circuits relevant to Parkinson’s disease.

We offer

Lund University is a governmental authority, which means you get special benefits, generous holidays, and a favorable occupational pension. Read more on the university's website about being employed at Lund University, Work at Lund University

Work description

The overarching aim is to characterise the molecular and anatomical organisation of the human subthalamic region and investigate the functional relevance of selected neural populations using optogenetic approaches in mice.

The work is primarily laboratory-based and involves hands-on experimental research, including:

• Molecular and anatomical mapping: Histological analysis of human, mouse and macaque brain tissue using techniques such as in situ hybridisation and immunohistochemistry, followed by microscopy, image analysis and spatial reconstruction.
• Optogenetic and behavioural studies: PCR-based genotyping, stereotactic brain surgery, viral vector delivery and optical fibre implantation, optogenetic manipulation of neural circuits, and behavioural assessment in mouse models relevant to Parkinson’s disease.
• Molecular and spatial data integration: Integration of histological and molecular findings with existing MRI-based anatomical datasets and DBS stimulation data from clinical and preclinical studies.
• Research communication and collaboration: Analysis, interpretation and presentation of research findings, including preparation of scientific manuscripts and presentations at national and international meetings.

Basis for assessment

This is a merit-based position primarily focused on research. The position is intended as an initial step in the academic career, and the selection will be based primarily on scientific merit and potential as a researcher. Particular emphasis will be placed on demonstrated scientific skills within the subject area.